Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair

doi:10.1111/j.1432-2277.2006.00407.x

	Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair
	Zhang, Dingguo ; Zhang, Fumin ; Zhang, Yuqing ; Gao, Xiang ; Li, Chuanfu ; Yang, Naiquan ; Cao, Kejiang
	2007-02-01
发表期刊	TRANSPLANT INTERNATIONAL
ISSN	0934-0874
卷号	20 期号:2 页码:174-183
摘要	We postulated that combining erythropoietin (EPO) infusion with bone marrow mesenchymal stem cells (MSC) delivery may give better prognosis in a rat infarcted heart. Acute myocardial infarction (MI) model was developed by coronary artery ligation. Animals were grouped (n = 18) to receive intramyocardial injection of 30 mu l saline solution without cells (EPO and control groups) or with 3 x 10(6) MSC from transgenic green fluorescent protein (GFP)+ male mice (MSC and MSC-EPO groups). The animals received either 5000 U/kg body weight EPO (EPO and MSC-EPO groups) or saline solution (MSC and control groups) for 7 days after MI. Cardiac functions were measured by echocardiography and cardiac tissue was harvested for immunohistological studies 3 weeks after surgery. We observed regeneration of MSC in and around the infarcted myocardium in MSC and MSC-EPO groups. Capillary density was markedly enhanced with significantly smaller infarct size and reduced fibrotic area in MSC-EPO group as compared with other three groups. A smaller left ventricular (LV) diastolic dimension and a higher LV fractional shortening were observed in MSC-EPO group than in other three groups. Transplantation of MSC combined with cytokine EPO is superior to either of the monotherapy approach for angiomyogenesis and cardiac function recovery.
关键词	bone marrow cells erythropoietin myocardial infarction
DOI	10.1111/j.1432-2277.2006.00407.x
语种	英语
关键词[WOS]	MESENCHYMAL STEM-CELLS ; MYOCARDIAL-INFARCTION ; HEART-FAILURE ; STROMAL CELLS ; PARACRINE MECHANISMS ; ANGIOGENESIS ; ISCHEMIA ; REGENERATION ; REPERFUSION ; MODEL
WOS研究方向	Surgery ; Transplantation
WOS类目	Surgery ; Transplantation
WOS记录号	WOS:000243534800009
出版者	BLACKWELL PUBLISHING
文献类型	期刊论文
条目标识符	http://ir.nigpas.ac.cn/handle/332004/108
专题	中国科学院南京地质古生物研究所
通讯作者	Zhang, Fumin
作者单位	1.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Peoples R China 2.Nanjing Univ, Nanjing Inst Geol & Paleontol, Nanjing 210008, Peoples R China 3.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210008, Peoples R China 4.E Tennessee State Univ, Dept Surg, Johnson City, TN 37614 USA
推荐引用方式 GB/T 7714	Zhang, Dingguo,Zhang, Fumin,Zhang, Yuqing,et al. Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair[J]. TRANSPLANT INTERNATIONAL,2007,20(2):174-183.
APA	Zhang, Dingguo.,Zhang, Fumin.,Zhang, Yuqing.,Gao, Xiang.,Li, Chuanfu.,...&Cao, Kejiang.(2007).Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair.TRANSPLANT INTERNATIONAL,20(2),174-183.
MLA	Zhang, Dingguo,et al."Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair".TRANSPLANT INTERNATIONAL 20.2(2007):174-183.